The genetics of neurodevelopmental disease
نویسندگان
چکیده
منابع مشابه
The genetics of neurodevelopmental disease.
The term neurodevelopmental disorder encompasses a wide range of diseases, including recognizably distinct syndromes known to be caused by very rare mutations in specific genes or chromosomal loci, and also much more common disorders such as schizophrenia, autism spectrum disorders, and idiopathic epilepsy and mental retardation. After decades of frustration, the past couple of years have sudde...
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CC-BY 4.0 International license peer-reviewed) is the author/funder. It is made available under a The copyright holder for this preprint (which was not. Introduction " our incomplete studies do not permit actual classification; but it is better to leave things by themselves rather than to force them into classes which have their foundation only on paper " – Edouard Seguin 1 " The fundamental mi...
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A dysfunction of cortical and limbic GABAergic circuits has been postulated to contribute to multiple neurodevelopmental disorders in humans, including schizophrenia, autism, and epilepsy. In the current paper, I summarize the characteristics that underlie the great diversity of cortical GABAergic interneurons and explore how the multiple roles of these cells in developing and mature circuits m...
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ژورنال
عنوان ژورنال: Current Opinion in Neurobiology
سال: 2011
ISSN: 0959-4388
DOI: 10.1016/j.conb.2010.08.009